"proliferation of cytotoxic and activated t cells during acute epstein-barr virus induced infectious mononucleosis "

نویسندگان

mansoori sd

shahgasempour s

چکیده

the immune responses that develop following epstien-barr virus (ebv) infection are complex and involve both humoral and to a greater extent cell-mediated immune mechanisms. to evaluate the immune response, flow cytometric analysis of the peripheral blood of six patients during the acute phase of ebv infection was performed. this analysis revealed a significant increase in the percentages and the absolute number of cd8+cytotoxic and activated (hla-dr+ - t lymphocytes and in some cases with a concomitan decrease in the percentages of b (cd19+) lymphocytes and t helper (cd4+) lymphocytes. these patient invariably had inverted cd4/cd8 ratio. all changes reversed to normal level during the recovery phase of infection. it is therefore concluded that ebv specific cytotoxic and activated t lymphocytes are essential in controlling acute ebv infection presented by the infected b cells.

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عنوان ژورنال:
acta medica iranica

جلد ۴۰، شماره ۱، صفحات ۶-۱۰

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